6HM7

CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE (SYK) IN COMPLEX WITH A 2-(PHENOXYMETHYL)PYRIDINE INHIBITOR

6HM7 の概要

• エントリーDOI: 10.2210/pdb6hm7/pdb
• 関連するPDBエントリー: 6HM6
• 分子名称: Tyrosine-protein kinase SYK, 7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1~{H}-3-benzazepine, BROMIDE ION, ... (6 entities in total)
• 機能のキーワード: sk363, syk, non-receptor tyrosine kinase, spleen tyrosine kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32889.35

構造登録者

Somers, D.O. (登録日: 2018-09-12, 公開日: 2018-10-10, 最終更新日: 2024-11-20)

主引用文献

Barker, M.D.,Liddle, J.,Atkinson, F.L.,Wilson, D.M.,Dickson, M.C.,Ramirez-Molina, C.,Lewis, H.,Davis, R.P.,Somers, D.O.,Neu, M.,Jones, E.,Watson, R.
Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease.
Bioorg. Med. Chem. Lett., 28:3458-3462, 2018

PubMed Abstract: The discovery and lead optimisation of a novel series of SYK inhibitors is described. These were optimised for SYK potency and selectivity against Aurora B. Compounds were profiled in a human skin penetration study to identify a suitable candidate molecule for pre-clinical development. Compound 44 (GSK2646264) was selected for progression and is currently in Phase I clinical trials.

PubMed: 30249354
DOI: 10.1016/j.bmcl.2018.09.022

実験手法

X-RAY DIFFRACTION (1.64 Å)