6HM0
Crystal structure of human BRD9 bromodomain in complex with a PROTAC
Summary for 6HM0
Entry DOI | 10.2210/pdb6hm0/pdb |
Descriptor | Bromodomain-containing protein 9, (2~{S},4~{S})-1-[(2~{S})-2-[2-[2-[2-[4-[[2,6-dimethoxy-4-(2-methyl-1-oxidanylidene-2,7-naphthyridin-4-yl)phenyl]methyl]piperazin-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide (3 entities in total) |
Functional Keywords | protac, lysine-acetylated histone binding, chromatin regulator, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 30405.84 |
Authors | Hughes, S.J.,Zoppi, V.,Ciulli, A. (deposition date: 2018-09-11, release date: 2019-01-16, Last modification date: 2024-01-24) |
Primary citation | Zoppi, V.,Hughes, S.J.,Maniaci, C.,Testa, A.,Gmaschitz, T.,Wieshofer, C.,Koegl, M.,Riching, K.M.,Daniels, D.L.,Spallarossa, A.,Ciulli, A. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J.Med.Chem., 62:699-726, 2019 Cited by PubMed: 30540463DOI: 10.1021/acs.jmedchem.8b01413 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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