6HM0
Crystal structure of human BRD9 bromodomain in complex with a PROTAC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bromodomain-containing protein 9 | polymer | 123 | 14249.8 | 2 | UniProt (Q9H8M2) Pfam (PF00439) In PDB | Homo sapiens (Human) | Rhabdomyosarcoma antigen MU-RMS-40.8 |
| 2 | A, B | (2~{S},4~{S})-1-[(2~{S})-2-[2-[2-[2-[4-[[2,6-dimethoxy-4-(2-methyl-1-oxidanylidene-2,7-naphthyridin-4-yl)phenyl]methyl]piperazin-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 953.2 | 2 | Chemie (GBW) | |||
| 3 | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence modifications
A, B: 14 - 134 (UniProt: Q9H8M2)
| PDB | External Database | Details |
|---|---|---|
| Ser 12 | - | expression tag |
| Met 13 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28499.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1906.3 | |
| All* | Total formula weight | 30405.8 |
