6HLP

Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Netupitant

Summary for 6HLP

Entry DOI	10.2210/pdb6hlp/pdb
Descriptor	Substance-P receptor,Substance-P receptor, 2-[3,5-bis(trifluoromethyl)phenyl]-~{N},2-dimethyl-~{N}-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide, CITRIC ACID, ... (7 entities in total)
Functional Keywords	7-tm; gpcr; signalling protein, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	67503.68
Authors	Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A. (deposition date: 2018-09-11, release date: 2019-01-16, Last modification date: 2024-01-24)
Primary citation	Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A. Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nat Commun, 10:17-17, 2019 Cited by PubMed: 30604743 DOI: 10.1038/s41467-018-07939-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation