6HKZ

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a inhibitor RNA 2-49-1

Summary for 6HKZ

• Entry DOI: 10.2210/pdb6hkz/pdb
• Descriptor: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; urea based inhibitor, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 82941.03

Authors

Motlova, L.,Novakova, Z.,Barinka, C. (deposition date: 2018-09-09, release date: 2018-12-05, Last modification date: 2024-01-24)

• Primary citation: Nakajima, R.,Novakova, Z.,Tueckmantel, W.,Motlova, L.,Barinka, C.,Kozikowski, A.P.; 2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands for Potential Use as Theranostics.; ACS Med Chem Lett, 9:1099-1104, 2018; PubMed: 30429952; DOI: 10.1021/acsmedchemlett.8b00318

Experimental method

X-RAY DIFFRACTION (2.09 Å)