Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide

Summary for 6HKS

DescriptorTyrosine-protein phosphatase non-receptor type 3, Protein E6, IODIDE ION, ... (4 entities in total)
Functional Keywordspdz domain protein tyrosine phosphatase human papillomavirus e6 oncoprotein pdz binding motif, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains12
Total molecular weight85378.2
Genera, M.,Haouz, A.,Caillet-Saguy, C. (deposition date: 2018-09-07, release date: 2019-05-22, Last modification date: 2019-05-29)
Primary citation
Genera, M.,Samson, D.,Raynal, B.,Haouz, A.,Baron, B.,Simenel, C.,Guerois, R.,Wolff, N.,Caillet-Saguy, C.
Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein.
Sci Rep, 9:7438-7438, 2019
PubMed: 31092861 (PDB entries with the same primary citation)
DOI: 10.1038/s41598-019-43932-x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.19441072073 Å)

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2477 0.4% 1.9% 1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution