6HKS

Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide

Summary for 6HKS

Entry DOI	10.2210/pdb6hks/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 3, Protein E6, IODIDE ION, ... (4 entities in total)
Functional Keywords	pdz domain protein tyrosine phosphatase human papillomavirus e6 oncoprotein pdz binding motif, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	85378.20
Authors	Genera, M.,Haouz, A.,Caillet-Saguy, C. (deposition date: 2018-09-07, release date: 2019-05-22, Last modification date: 2024-01-17)
Primary citation	Genera, M.,Samson, D.,Raynal, B.,Haouz, A.,Baron, B.,Simenel, C.,Guerois, R.,Wolff, N.,Caillet-Saguy, C. Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein. Sci Rep, 9:7438-7438, 2019 Cited by PubMed: 31092861 DOI: 10.1038/s41598-019-43932-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19441072073 Å)

Structure validation