6HJ7
The NMR structure of NRADD death domain
Summary for 6HJ7
| Entry DOI | 10.2210/pdb6hj7/pdb |
| Descriptor | Death domain-containing membrane protein NRADD (1 entity in total) |
| Functional Keywords | nraad, p45, p75 neurotrophin receptor, bicelles, membrane protein |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 1 |
| Total formula weight | 26664.05 |
| Authors | Nadezhdin, K.D.,Mineev, K.S.,Goncharuk, S.A.,Arseniev, A.S. (deposition date: 2018-09-01, release date: 2019-05-08, Last modification date: 2024-06-19) |
| Primary citation | Nadezhdin, K.D.,Goncharuk, S.A.,Arseniev, A.S.,Mineev, K.S. NMR structure of a full-length single-pass membrane protein NRADD. Proteins, 87:786-790, 2019 Cited by PubMed Abstract: Structural study of any single-pass membrane protein is both an important and challenging task. In this report, we present the structure of a neurotrophin receptor-alike death-domain protein. The structure and dynamics of the protein was investigated by conventional nuclear magnetic resonance techniques in the solution of phospholipid bicelles. The receptor contains two folded regions-α-helical transmembrane domain and globular C-terminal death domain with more than 50% of the rest of backbone being disordered. This is the first structure of a full-length single-pass membrane receptor-alike protein solved by the single method. PubMed: 31033000DOI: 10.1002/prot.25703 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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