6HIZ

Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains the head of the small mitoribosomal subunit

これはPDB形式変換不可エントリーです。

6HIZ の概要

• エントリーDOI: 10.2210/pdb6hiz/pdb
• EMDBエントリー: 0233
• 分子名称: mS48, mS58, mS67, ... (33 entities in total)
• 機能のキーワード: mitoribosome, translation, trypanosoma, small ribosomal subunit, 9s rrna, ribosomal protein, ribosome
• 由来する生物種: Trypanosoma brucei brucei; 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 1650366.57

構造登録者

Ramrath, D.J.F.,Niemann, M.,Leibundgut, M.,Bieri, P.,Prange, C.,Horn, E.K.,Leitner, A.,Boehringer, A.,Schneider, A.,Ban, N. (登録日: 2018-08-31, 公開日: 2018-09-26, 最終更新日: 2024-05-15)

主引用文献

Ramrath, D.J.F.,Niemann, M.,Leibundgut, M.,Bieri, P.,Prange, C.,Horn, E.K.,Leitner, A.,Boehringer, D.,Schneider, A.,Ban, N.
Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Science, 362:-, 2018

PubMed Abstract: Ribosomal RNA (rRNA) plays key functional and architectural roles in ribosomes. Using electron microscopy, we determined the atomic structure of a highly divergent ribosome found in mitochondria of , a unicellular parasite that causes sleeping sickness in humans. The trypanosomal mitoribosome features the smallest rRNAs and contains more proteins than all known ribosomes. The structure shows how the proteins have taken over the role of architectural scaffold from the rRNA: They form an autonomous outer shell that surrounds the entire particle and stabilizes and positions the functionally important regions of the rRNA. Our results also reveal the "minimal" set of conserved rRNA and protein components shared by all ribosomes that help us define the most essential functional elements.

PubMed: 30213880
DOI: 10.1126/science.aau7735

実験手法

ELECTRON MICROSCOPY (3.08 Å)