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6HI7

The ATAD2 bromodomain in complex with compound 10

Summary for 6HI7
Entry DOI10.2210/pdb6hi7/pdb
DescriptorATPase family AAA domain-containing protein 2, SULFATE ION, (2~{R})-~{N}-[5-(3-aminophenyl)-4-ethanoyl-1,3-thiazol-2-yl]-2-azanyl-propanamide, ... (4 entities in total)
Functional Keywordsbromodomain, atad2, inhibitor, complex, cytosolic protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight15950.01
Authors
Sledz, P.,Caflisch, A. (deposition date: 2018-08-29, release date: 2019-02-20, Last modification date: 2024-01-17)
Primary citationDolbois, A.,Batiste, L.,Wiedmer, L.,Dong, J.,Brutsch, M.,Huang, D.,Deerain, N.M.,Spiliotopoulos, D.,Cheng-Sanchez, I.,Laul, E.,Nevado, C.,Sledz, P.,Caflisch, A.
Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.
Acs Med.Chem.Lett., 11:1573-1580, 2020
Cited by
PubMed: 32832026
DOI: 10.1021/acsmedchemlett.0c00080
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.743 Å)
Structure validation

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