6HHC
Allosteric Inhibition as a new mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated form of Coagulation Factor XI
Summary for 6HHC
| Entry DOI | 10.2210/pdb6hhc/pdb |
| Descriptor | FXIA ANTIBODY FAB LIGHT CHAIN, FXIA ANTIBODY FAB HEAVY CHAIN, Coagulation factor XI, ... (5 entities in total) |
| Functional Keywords | fxia antibody fab, blood clotting, blood clotting-immune complex |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 74655.43 |
| Authors | Schaefer, M.,Buchmueller, A.,Dittmer, F.,Strassburger, J.,Wilmen, A. (deposition date: 2018-08-27, release date: 2019-09-11, Last modification date: 2024-01-17) |
| Primary citation | Schaefer, M.,Buchmueller, A.,Dittmer, F.,Strassburger, J.,Wilmen, A. Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI. J.Mol.Biol., 431:4817-4833, 2019 Cited by PubMed: 31655039DOI: 10.1016/j.jmb.2019.09.008 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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