6HHC
Allosteric Inhibition as a new mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated form of Coagulation Factor XI
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | FXIA ANTIBODY FAB LIGHT CHAIN | polymer | 216 | 23496.9 | 1 | Homo sapiens (Human) | ||
| 2 | B (H) | FXIA ANTIBODY FAB HEAVY CHAIN | polymer | 227 | 23935.7 | 1 | Homo sapiens (Human) | ||
| 3 | C (A) | Coagulation factor XI | polymer | 238 | 26856.5 | 1 | UniProt (P03951) Pfam (PF00089) | Homo sapiens (Human) | FXI,Plasma thromboplastin antecedent,PTA |
| 4 | D, E, F (H) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | G (H) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) |
Sequence modifications
A: 388 - 625 (UniProt: P03951)
| PDB | External Database | Details |
|---|---|---|
| Ser 500 | Cys 500 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 74289.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 366.3 | |
| All* | Total formula weight | 74655.4 |
