6HHC

Allosteric Inhibition as a new mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated form of Coagulation Factor XI

6HHC の概要

• エントリーDOI: 10.2210/pdb6hhc/pdb
• 分子名称: FXIA ANTIBODY FAB LIGHT CHAIN, FXIA ANTIBODY FAB HEAVY CHAIN, Coagulation factor XI, ... (5 entities in total)
• 機能のキーワード: fxia antibody fab, blood clotting, blood clotting-immune complex
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 74655.43

構造登録者

Schaefer, M.,Buchmueller, A.,Dittmer, F.,Strassburger, J.,Wilmen, A. (登録日: 2018-08-27, 公開日: 2019-09-11, 最終更新日: 2024-01-17)

• 主引用文献: Schaefer, M.,Buchmueller, A.,Dittmer, F.,Strassburger, J.,Wilmen, A.; Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI.; J.Mol.Biol., 431:4817-4833, 2019; PubMed: 31655039; DOI: 10.1016/j.jmb.2019.09.008

実験手法

X-RAY DIFFRACTION (2.7 Å)