6HGS

Crystal Structure of Human APRT wild type in complex with GMP

Summary for 6HGS

Entry DOI	10.2210/pdb6hgs/pdb
Related	6FCH 6FCI 6FCL 6FD4 6FD5 6FD6 6HGP 6HGQ 6HGR
Descriptor	Adenine phosphoribosyltransferase, GUANOSINE-5'-MONOPHOSPHATE (3 entities in total)
Functional Keywords	rossman fold, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	39581.35
Authors	Nioche, P.,Huyet, J.,Ozeir, M. (deposition date: 2018-08-23, release date: 2019-07-31, Last modification date: 2024-01-17)
Primary citation	Ozeir, M.,Huyet, J.,Burgevin, M.C.,Pinson, B.,Chesney, F.,Remy, J.M.,Siddiqi, A.R.,Lupoli, R.,Pinon, G.,Saint-Marc, C.,Gibert, J.F.,Morales, R.,Ceballos-Picot, I.,Barouki, R.,Daignan-Fornier, B.,Olivier-Bandini, A.,Auge, F.,Nioche, P. Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction. J.Biol.Chem., 294:11980-11991, 2019 Cited by PubMed: 31160323 DOI: 10.1074/jbc.RA119.009087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation