6HGQ
Crystal Structure of Human APRT wild type in complex with Hypoxanthine, PRPP and Mg2+
Summary for 6HGQ
| Entry DOI | 10.2210/pdb6hgq/pdb |
| Related | 6FCH 6FCI 6FCL 6FD4 6FD5 6FD6 6HPG |
| Descriptor | Adenine phosphoribosyltransferase, GLYCEROL, MAGNESIUM ION, ... (6 entities in total) |
| Functional Keywords | rossman fold, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 80288.16 |
| Authors | Nioche, P.,Huyet, J.,Ozeir, M. (deposition date: 2018-08-23, release date: 2019-07-31, Last modification date: 2024-01-17) |
| Primary citation | Ozeir, M.,Huyet, J.,Burgevin, M.C.,Pinson, B.,Chesney, F.,Remy, J.M.,Siddiqi, A.R.,Lupoli, R.,Pinon, G.,Saint-Marc, C.,Gibert, J.F.,Morales, R.,Ceballos-Picot, I.,Barouki, R.,Daignan-Fornier, B.,Olivier-Bandini, A.,Auge, F.,Nioche, P. Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction. J.Biol.Chem., 294:11980-11991, 2019 Cited by PubMed: 31160323DOI: 10.1074/jbc.RA119.009087 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report
