6HF5
Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-431 Inhibitor
Summary for 6HF5
Entry DOI | 10.2210/pdb6hf5/pdb |
Related | 5MXQ 5MXR |
Descriptor | Beta-lactamase class B VIM-2, ZINC ION, ACETATE ION, ... (5 entities in total) |
Functional Keywords | metallo-beta-lactamase fold, zinc-dependent hydrolase, pfam00753, alpha-beta-beta-alpha sandwich, hydrolase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 1 |
Total formula weight | 25279.05 |
Authors | Docquier, J.D.,Pozzi, C.,De Luca, F.,Benvenuti, M.,Mangani, S. (deposition date: 2018-08-21, release date: 2018-12-05, Last modification date: 2024-01-17) |
Primary citation | Leiris, S.,Coelho, A.,Castandet, J.,Bayet, M.,Lozano, C.,Bougnon, J.,Bousquet, J.,Everett, M.,Lemonnier, M.,Sprynski, N.,Zalacain, M.,Pallin, T.D.,Cramp, M.C.,Jennings, N.,Raphy, G.,Jones, M.W.,Pattipati, R.,Shankar, B.,Sivasubrahmanyam, R.,Soodhagani, A.K.,Juventhala, R.R.,Pottabathini, N.,Pothukanuri, S.,Benvenuti, M.,Pozzi, C.,Mangani, S.,De Luca, F.,Cerboni, G.,Docquier, J.D.,Davies, D.T. SAR Studies Leading to the Identification of a Novel Series of Metallo-beta-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model. Acs Infect Dis., 5:131-140, 2019 Cited by PubMed: 30427656DOI: 10.1021/acsinfecdis.8b00246 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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