6HF5

Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-431 Inhibitor

Summary for 6HF5

• Entry DOI: 10.2210/pdb6hf5/pdb
• Related: 5MXQ 5MXR
• Descriptor: Beta-lactamase class B VIM-2, ZINC ION, ACETATE ION, ... (5 entities in total)
• Functional Keywords: metallo-beta-lactamase fold, zinc-dependent hydrolase, pfam00753, alpha-beta-beta-alpha sandwich, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 25279.05

Authors

Docquier, J.D.,Pozzi, C.,De Luca, F.,Benvenuti, M.,Mangani, S. (deposition date: 2018-08-21, release date: 2018-12-05, Last modification date: 2024-01-17)

• Primary citation: Leiris, S.,Coelho, A.,Castandet, J.,Bayet, M.,Lozano, C.,Bougnon, J.,Bousquet, J.,Everett, M.,Lemonnier, M.,Sprynski, N.,Zalacain, M.,Pallin, T.D.,Cramp, M.C.,Jennings, N.,Raphy, G.,Jones, M.W.,Pattipati, R.,Shankar, B.,Sivasubrahmanyam, R.,Soodhagani, A.K.,Juventhala, R.R.,Pottabathini, N.,Pothukanuri, S.,Benvenuti, M.,Pozzi, C.,Mangani, S.,De Luca, F.,Cerboni, G.,Docquier, J.D.,Davies, D.T.; SAR Studies Leading to the Identification of a Novel Series of Metallo-beta-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.; Acs Infect Dis., 5:131-140, 2019; PubMed: 30427656; DOI: 10.1021/acsinfecdis.8b00246

Experimental method

X-RAY DIFFRACTION (1.8 Å)