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6HEY

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative ATNK002

Summary for 6HEY
Entry DOI10.2210/pdb6hey/pdb
DescriptorEphrin type-A receptor 2, 3-[(4,6-dipyridin-3-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide (3 entities in total)
Functional Keywordsinhibitor, complex, protein tyrosine kinase, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight34990.34
Authors
Kudlinzki, D.,Troester, A.,Witt, K.,Linhard, V.L.,Gande, S.L.,Saxena, K.,Schwalbe, H. (deposition date: 2018-08-20, release date: 2019-08-28, Last modification date: 2024-01-17)
Primary citationTroester, A.,Kudlinzki, D.,Saxena, K.,Gande, S.,Schwalbe, H.
Effects of NVP-BHG712 chemical modifications on EPHA2 binding and affinity
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.367 Å)
Structure validation

217705

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