6HDY

Crystal structure of 2-Hydroxyisobutyryl-CoA Ligase (HCL) in the postadenylation state in complex with S3-HB-AMP

Summary for 6HDY

Entry DOI	10.2210/pdb6hdy/pdb
Descriptor	2-hydroxyisobutyryl-CoA synthetase, (3S)-3-HYDROXYBUTANOIC ACID, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (3~{S})-3-oxidanylbutanoate, ... (5 entities in total)
Functional Keywords	ligase, 2-hydroxyisobutyrate coa
Biological source	Aquincola tertiaricarbonis
Total number of polymer chains	1
Total formula weight	56768.67
Authors	Zahn, M.,Rohwerder, T.,Strater, N. (deposition date: 2018-08-20, release date: 2019-08-28, Last modification date: 2024-01-17)
Primary citation	Zahn, M.,Kurteva-Yaneva, N.,Schuster, J.,Krug, U.,Georgi, T.,Muller, R.H.,Rohwerder, T.,Strater, N. Structures of 2-Hydroxyisobutyric Acid-CoA Ligase Reveal Determinants of Substrate Specificity and Describe a Multi-Conformational Catalytic Cycle. J.Mol.Biol., 431:2747-2761, 2019 Cited by PubMed: 31145912 DOI: 10.1016/j.jmb.2019.05.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation