6HCC
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 1.6 A RESOLUTION.
Summary for 6HCC
Entry DOI | 10.2210/pdb6hcc/pdb |
Descriptor | Glutamate receptor 2, 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE), GLUTAMIC ACID, ... (9 entities in total) |
Functional Keywords | ampa receptor, glua2, ligand-binding domain, glua2-s1s2j-n775s, membrane protein, signaling protein, positive allosteric modulator |
Biological source | Rattus norvegicus (Norway Rat) More |
Total number of polymer chains | 2 |
Total formula weight | 60952.02 |
Authors | Laulumaa, S.,Hansen, K.V.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2018-08-14, release date: 2019-04-03, Last modification date: 2024-01-17) |
Primary citation | Laulumaa, S.,Hansen, K.V.,Masternak, M.,Drapier, T.,Francotte, P.,Pirotte, B.,Frydenvang, K.,Kastrup, J.S. Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. Acs Med.Chem.Lett., 10:243-247, 2019 Cited by PubMed: 30891120DOI: 10.1021/acsmedchemlett.8b00369 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.617 Å) |
Structure validation
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