6HCC

STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 1.6 A RESOLUTION.

6HCC の概要

• エントリーDOI: 10.2210/pdb6hcc/pdb
• 分子名称: Glutamate receptor 2, 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE), GLUTAMIC ACID, ... (9 entities in total)
• 機能のキーワード: ampa receptor, glua2, ligand-binding domain, glua2-s1s2j-n775s, membrane protein, signaling protein, positive allosteric modulator
• 由来する生物種: Rattus norvegicus (Norway Rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60952.02

構造登録者

Laulumaa, S.,Hansen, K.V.,Frydenvang, K.,Kastrup, J.S. (登録日: 2018-08-14, 公開日: 2019-04-03, 最終更新日: 2024-01-17)

• 主引用文献: Laulumaa, S.,Hansen, K.V.,Masternak, M.,Drapier, T.,Francotte, P.,Pirotte, B.,Frydenvang, K.,Kastrup, J.S.; Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.; Acs Med.Chem.Lett., 10:243-247, 2019; PubMed: 30891120; DOI: 10.1021/acsmedchemlett.8b00369

実験手法

X-RAY DIFFRACTION (1.617 Å)