6HC2

Crystal structure of NuMA/LGN hetero-hexamers

Summary for 6HC2

• Entry DOI: 10.2210/pdb6hc2/pdb
• Descriptor: G-protein-signaling modulator 2, Nuclear mitotic apparatus protein 1 (2 entities in total)
• Functional Keywords: cell division asymmetric cell division spindle orientation force generator, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 24
• Total formula weight: 582036.46

Authors

Pasqualato, S.,Culurgioni, S.,Foadi, J.,Alfieri, A.,Mapelli, M. (deposition date: 2018-08-13, release date: 2019-05-29, Last modification date: 2024-01-17)

• Primary citation: Pirovano, L.,Culurgioni, S.,Carminati, M.,Alfieri, A.,Monzani, S.,Cecatiello, V.,Gaddoni, C.,Rizzelli, F.,Foadi, J.,Pasqualato, S.,Mapelli, M.; Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions.; Nat Commun, 10:2208-2208, 2019; PubMed: 31101817; DOI: 10.1038/s41467-019-09999-w

Experimental method

X-RAY DIFFRACTION (4.31 Å)