6HAW

Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7

6HAW の概要

• エントリーDOI: 10.2210/pdb6haw/pdb
• 分子名称: Cytochrome b-c1 complex subunit 1, mitochondrial, Cytochrome b-c1 complex subunit 9, 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... (24 entities in total)
• 機能のキーワード: cytochrome bc1, malaria, electron transport
• 由来する生物種: Bos taurus (cattle); 詳細
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 238530.04

構造登録者

Amporndanai, K.,Hong, W.D.,O'Neill, P.M.,Hasnain, S.S.,Antonyuk, S.V. (登録日: 2018-08-08, 公開日: 2019-01-16, 最終更新日: 2024-01-17)

• 主引用文献: David Hong, W.,Leung, S.C.,Amporndanai, K.,Davies, J.,Priestley, R.S.,Nixon, G.L.,Berry, N.G.,Samar Hasnain, S.,Antonyuk, S.,Ward, S.A.,Biagini, G.A.,O'Neill, P.M.; Potent Antimalarial 2-Pyrazolyl Quinolonebc1(Qi) Inhibitors with Improved Drug-like Properties.; ACS Med Chem Lett, 9:1205-1210, 2018; PubMed: 30613327; DOI: 10.1021/acsmedchemlett.8b00371

実験手法

X-RAY DIFFRACTION (3.45 Å)