6HAR
Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C
Summary for 6HAR
Entry DOI | 10.2210/pdb6har/pdb |
Descriptor | PRSS3 protein, Amyloid-beta A4 protein, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | prss3, mesotrypsin, serine protease, kunitz type inhibitor, appi, protein fibril |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 33430.50 |
Authors | Shahar, A.,Cohen, I.,Radisky, E.,Papo, N. (deposition date: 2018-08-08, release date: 2019-02-06, Last modification date: 2024-01-17) |
Primary citation | Cohen, I.,Coban, M.,Shahar, A.,Sankaran, B.,Hockla, A.,Lacham, S.,Caulfield, T.R.,Radisky, E.S.,Papo, N. Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J.Biol.Chem., 294:5105-5120, 2019 Cited by PubMed: 30700553DOI: 10.1074/jbc.RA118.007292 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.497 Å) |
Structure validation
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