Summary for 6H8T
| Entry DOI | 10.2210/pdb6h8t/pdb |
| Descriptor | Papain, ACETATE ION, CHLORIDE ION, ... (8 entities in total) |
| Functional Keywords | artificial metalloenzyme hydroxylation ruthenium complex, metal binding protein |
| Biological source | Carica papaya (Papaya) |
| Total number of polymer chains | 2 |
| Total formula weight | 48458.30 |
| Authors | Cherrier, M.V.,Amara, P.,Talbi, B.,Salmin, M.,Fontecilla-Camps, J.C. (deposition date: 2018-08-03, release date: 2018-09-12, Last modification date: 2025-10-01) |
| Primary citation | Cherrier, M.V.,Amara, P.,Talbi, B.,Salmain, M.,Fontecilla-Camps, J.C. Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate. Metallomics, 10:1452-1459, 2018 Cited by PubMed Abstract: The X-ray structure of an aerated achiral Ru-papain conjugate has revealed the hydroxylation of two tyrosine residues found near the ruthenium ion. The most likely mechanism involves a ruthenium-bound superoxide as the reactive species responsible for the first hydroxylation and the resulting high valent Ru(iv)[double bond, length as m-dash]O species for the second one. PubMed: 30175357DOI: 10.1039/c8mt00160j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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