6H5O
Crystal structure of PBP2a from MRSA in complex with piperacillin at active site.
Summary for 6H5O
Entry DOI | 10.2210/pdb6h5o/pdb |
Descriptor | Penicillin binding protein 2 prime, Piperacillin (Open Form), CADMIUM ION, ... (4 entities in total) |
Functional Keywords | penicillin binding protein, hydrolase |
Biological source | Staphylococcus aureus (strain Mu50 / ATCC 700699) |
Total number of polymer chains | 2 |
Total formula weight | 148624.15 |
Authors | Batuecas, M.T.,Martinez-Caballero, S.,Hermoso, J.A. (deposition date: 2018-07-25, release date: 2019-08-14, Last modification date: 2024-01-17) |
Primary citation | Janardhanan, J.,Bouley, R.,Martinez-Caballero, S.,Peng, Z.,Batuecas-Mordillo, M.,Meisel, J.E.,Ding, D.,Schroeder, V.A.,Wolter, W.R.,Mahasenan, K.V.,Hermoso, J.A.,Mobashery, S.,Chang, M. The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus. Antimicrob.Agents Chemother., 63:-, 2019 Cited by PubMed: 30858202DOI: 10.1128/AAC.02637-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.82 Å) |
Structure validation
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