6H4G
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei: E311A, T318R, V319A mutant bound to cAMP in the A site
Summary for 6H4G
Entry DOI | 10.2210/pdb6h4g/pdb |
Related | 6FLO |
Descriptor | Protein kinase A regulatory subunit, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, INOSINE, ... (4 entities in total) |
Functional Keywords | protein kinase a, regulatory subunit, nucleoside-binding protein, signaling protein |
Biological source | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) |
Total number of polymer chains | 2 |
Total formula weight | 69960.92 |
Authors | Volpato Santos, Y.,Lorentzen, E.,Basquin, J.,Boshart, M. (deposition date: 2018-07-21, release date: 2019-08-14, Last modification date: 2024-01-17) |
Primary citation | Ober, V.,Githure, G.B.,Volpato Santos, Y.,Becker, S.,Moya, G.,Basquin, J.,Schwede, F.,Lorentzen, E.,Boshart, M. Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens Elife, 2023 Cited by DOI: 10.7554/eLife.91040.1PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14351698698 Å) |
Structure validation
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