6H47

Human KRAS in complex with darpin K19

Summary for 6H47

• Entry DOI: 10.2210/pdb6h47/pdb
• Descriptor: GTPase KRas, darpin K19, SULFATE ION, ... (4 entities in total)
• Functional Keywords: gtp-ase, darpin, kras signalling, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 39158.93

Authors

Debreczeni, J.E.,Bery, N.,Legg, S.,Breed, J.,Embrey, K.,Stubbs, C.,Kolasinska-Zwierz, P.,Barrett, N.,Marwood, R.,Watson, J.,Tart, J.,Overman, R.,Miller, A.,Phillips, C.,Minter, R.,Rabbitts, T.H. (deposition date: 2018-07-20, release date: 2019-04-24, Last modification date: 2019-06-26)

• Primary citation: Bery, N.,Legg, S.,Debreczeni, J.,Breed, J.,Embrey, K.,Stubbs, C.,Kolasinska-Zwierz, P.,Barrett, N.,Marwood, R.,Watson, J.,Tart, J.,Overman, R.,Miller, A.,Phillips, C.,Minter, R.,Rabbitts, T.H.; KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.; Nat Commun, 10:2607-2607, 2019; PubMed: 31197133; DOI: 10.1038/s41467-019-10419-2

Experimental method

X-RAY DIFFRACTION (1.7 Å)