6H39

Yeast 20S proteasome in complex with the peptidic non-covalent binding inhibitor RTS-V5

Summary for 6H39

• Entry DOI: 10.2210/pdb6h39/pdb
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (20 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, proteasome, histone-deacetylase, dual binding inhibitor, binding analysis, hydrolase
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Total number of polymer chains: 28
• Total formula weight: 732998.52

Authors

Groll, M.,Hansen, F.K. (deposition date: 2018-07-17, release date: 2018-11-07, Last modification date: 2024-01-17)

• Primary citation: Bhatia, S.,Krieger, V.,Groll, M.,Osko, J.D.,Reßing, N.,Ahlert, H.,Borkhardt, A.,Kurz, T.,Christianson, D.W.,Hauer, J.,Hansen, F.K.; Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor.; J. Med. Chem., 61:10299-10309, 2018; PubMed: 30365892; DOI: 10.1021/acs.jmedchem.8b01487

Experimental method

X-RAY DIFFRACTION (2.5 Å)