6H23
Crystal structure of the hClpP Y118A mutant with an activating small molecule
Summary for 6H23
Entry DOI | 10.2210/pdb6h23/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, mitochondrial, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-[(2-chloranyl-4-fluoranyl-phenyl)methyl]-1,3,4-oxadiazole-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | protease, small molecule, 14mer, serine protease, oligomerization, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 14 |
Total formula weight | 357664.49 |
Authors | Kick, L.M.,Sieber, S.A.,Schneider, S. (deposition date: 2018-07-13, release date: 2018-08-29, Last modification date: 2024-05-15) |
Primary citation | Stahl, M.,Korotkov, V.S.,Balogh, D.,Kick, L.M.,Gersch, M.,Pahl, A.,Kielkowski, P.,Richter, K.,Schneider, S.,Sieber, S.A. Selective Activation of Human Caseinolytic Protease P (ClpP). Angew. Chem. Int. Ed. Engl., 57:14602-14607, 2018 Cited by PubMed: 30129683DOI: 10.1002/anie.201808189 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.089 Å) |
Structure validation
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