6H23
Crystal structure of the hClpP Y118A mutant with an activating small molecule
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | ATP-dependent Clp protease proteolytic subunit, mitochondrial | polymer | 229 | 25140.0 | 14 | UniProt (Q16740) Pfam (PF00574) In PDB | Homo sapiens (Human) | Endopeptidase Clp |
2 | J, K, L, M, A... | ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-[(2-chloranyl-4-fluoranyl-phenyl)methyl]-1,3,4-oxadiazole-2-carboxamide | non-polymer | 389.8 | 14 | Chemie (FJT) | |||
3 | N, A, E, F | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
4 | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N: 57 - 277 (UniProt: Q16740)
PDB | External Database | Details |
---|---|---|
Ala 118 | Tyr 118 | engineered mutation |
Trp 278 | - | expression tag |
Ser 279 | - | expression tag |
His 280 | - | expression tag |
Pro 281 | - | expression tag |
Gln 282 | - | expression tag |
Phe 283 | - | expression tag |
Glu 284 | - | expression tag |
Lys 285 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 14 |
Total formula weight | 351959.5 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 5705.0 | |
All* | Total formula weight | 357664.5 |