6H23
Crystal structure of the hClpP Y118A mutant with an activating small molecule
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | ATP-dependent Clp protease proteolytic subunit, mitochondrial | polymer | 229 | 25140.0 | 14 | UniProt (Q16740) Pfam (PF00574) | Homo sapiens (Human) | Endopeptidase Clp |
| 2 | AA, BA, CA, DA, EA... (J, K, L, M, A...) | ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-[(2-chloranyl-4-fluoranyl-phenyl)methyl]-1,3,4-oxadiazole-2-carboxamide | non-polymer | 389.8 | 14 | Chemie (FJT) | |||
| 3 | FA, P, U, W (N, A, E, F) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | GA, HA, IA, JA, KA... (D, E, F, G, H...) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N: 57 - 277 (UniProt: Q16740)
| PDB | External Database | Details |
|---|---|---|
| Ala 118 | Tyr 118 | engineered mutation |
| Trp 278 | - | expression tag |
| Ser 279 | - | expression tag |
| His 280 | - | expression tag |
| Pro 281 | - | expression tag |
| Gln 282 | - | expression tag |
| Phe 283 | - | expression tag |
| Glu 284 | - | expression tag |
| Lys 285 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 351959.5 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 5705.0 | |
| All* | Total formula weight | 357664.5 |
