6H1F
Structure of the nanobody-stabilized gelsolin D187N variant (second domain)
Summary for 6H1F
| Entry DOI | 10.2210/pdb6h1f/pdb |
| Descriptor | gelsolin nanobody, Nb11, Gelsolin, THIOCYANATE ION, ... (4 entities in total) |
| Functional Keywords | amyloidosis, calcium, misfolding, nanobody, mutation, structural protein |
| Biological source | Lama glama (llama) More |
| Total number of polymer chains | 2 |
| Total formula weight | 28490.53 |
| Authors | Hassan, A.,Milani, M.,Mastrangelo, E.,de Rosa, M. (deposition date: 2018-07-11, release date: 2019-01-23, Last modification date: 2024-01-17) |
| Primary citation | Giorgino, T.,Mattioni, D.,Hassan, A.,Milani, M.,Mastrangelo, E.,Barbiroli, A.,Verhelle, A.,Gettemans, J.,Barzago, M.M.,Diomede, L.,de Rosa, M. Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant. Biochim Biophys Acta Mol Basis Dis, 1865:648-660, 2019 Cited by PubMed: 30625383DOI: 10.1016/j.bbadis.2019.01.010 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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