6H0F

Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2)

Summary for 6H0F

Entry DOI	10.2210/pdb6h0f/pdb
Descriptor	DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, DNA-binding protein Ikaros, ... (6 entities in total)
Functional Keywords	e3 ubiquitin ligase, drug mediated protein-interaction, targeted protein degradation, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	597390.68
Authors	Petzold, G.,Bunker, R.D.,Thoma, N.H. (deposition date: 2018-07-09, release date: 2018-11-07, Last modification date: 2024-01-17)
Primary citation	Sievers, Q.L.,Petzold, G.,Bunker, R.D.,Renneville, A.,Slabicki, M.,Liddicoat, B.J.,Abdulrahman, W.,Mikkelsen, T.,Ebert, B.L.,Thoma, N.H. Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science, 362:eaat0572-, 2018 Cited by PubMed: 30385546 DOI: 10.1126/science.aat0572 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation