Serum paraoxonase-1 by directed evolution with the L69G/H115W/H134R/F222S/T332S mutations

Summary for 6H0A

DescriptorSerum Paraoxonase-1 by directed evolution with the L69G/H115W/H134R/F222S/T332S mutations, CALCIUM ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total)
Functional Keywordsbeta-propeller, lactonase, hdl, organophosphate-hydrolase, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight40599.97
Ben-David, M.,Sussman, J.L.,Tawfik, D.S. (deposition date: 2018-07-07, release date: 2019-07-17)
Primary citation
Ben-David, M.,Tawfik, D.S.,Sussman, J.L.
An epistatic ratchet versus a reversible transition in the evolution of enzyme function
To Be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20530 1.4% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution