6GY1

rat COMT in complex with inhibitor

6GY1 の概要

• エントリーDOI: 10.2210/pdb6gy1/pdb
• 分子名称: Catechol O-methyltransferase, MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (6 entities in total)
• 機能のキーワード: magnesium ion binding, o-methyltransferase activity, neurotransmitter catabolic process, transferase
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25720.72

構造登録者

Schulze, M.-S. (登録日: 2018-06-27, 公開日: 2018-10-10, 最終更新日: 2024-01-17)

• 主引用文献: Buchler, I.,Akuma, D.,Au, V.,Carr, G.,de Leon, P.,DePasquale, M.,Ernst, G.,Huang, Y.,Kimos, M.,Kolobova, A.,Poslusney, M.,Wei, H.,Swinnen, D.,Montel, F.,Moureau, F.,Jigorel, E.,Schulze, M.E.D.,Wood, M.,Barrow, J.C.; Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.; J. Med. Chem., 61:9647-9665, 2018; PubMed: 30272964; DOI: 10.1021/acs.jmedchem.8b01126

実験手法

X-RAY DIFFRACTION (2.1 Å)