6GXY

Tryparedoxin from Trypanosoma brucei in complex with CFT

Summary for 6GXY

Related6GXG
DescriptorTryparedoxin, 5-(4-fluorophenyl)-2-methyl-3~{H}-thieno[2,3-d]pyrimidin-4-one (3 entities in total)
Functional Keywordscovalent inhibitor, photoreduction, inhibitor-induced dimerization, monomer-dimer mixture, oxidoreductase
Biological sourceTrypanosoma brucei brucei
Total number of polymer chains3
Total molecular weight48837.99
Authors
Bader, N.,Wagner, A.,Hellmich, U.,Schindelin, H. (deposition date: 2018-06-27, release date: 2019-01-16)
Primary citation
Wagner, A.,Le, T.A.,Brennich, M.,Klein, P.,Bader, N.,Diehl, E.,Paszek, D.,Weickhmann, A.K.,Dirdjaja, N.,Krauth-Siegel, R.L.,Engels, B.,Opatz, T.,Schindelin, H.,Hellmich, U.A.
Inhibitor-induced dimerization of an essential oxidoreductase from African Trypanosomes.
Angew. Chem. Int. Ed. Engl., 2019
PubMed: 30605929 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201810470
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22420 2.5% 3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6gxy
no rotation
Molmil generated image of 6gxy
rotated about x axis by 90°
Molmil generated image of 6gxy
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 6gxy
no rotation
Molmil generated image of 6gxy
rotated about x axis by 90°
Molmil generated image of 6gxy
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6gxy.pdb1.gz [60.2 KB])
Coordinate files for Biological unit (6gxy.pdb2.gz [31.13 KB])
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan