6GXG

Tryparedoxin from Trypanosoma brucei in complex with CFT

Summary for 6GXG

Entry DOI	10.2210/pdb6gxg/pdb
Descriptor	Tryparedoxin, 5-(4-fluorophenyl)-2-methyl-3~{H}-thieno[2,3-d]pyrimidin-4-one, GLYCEROL, ... (5 entities in total)
Functional Keywords	covalent inhibitor, photoreduction, inhibitor-induced dimerization, monomer-dimer mixture, oxidoreductase
Biological source	Trypanosoma brucei brucei More
Total number of polymer chains	3
Total formula weight	49024.19
Authors	Bader, N.,Wagner, A.,Hellmich, U.,Schindelin, H. (deposition date: 2018-06-27, release date: 2019-01-16, Last modification date: 2024-01-17)
Primary citation	Wagner, A.,Le, T.A.,Brennich, M.,Klein, P.,Bader, N.,Diehl, E.,Paszek, D.,Weickhmann, A.K.,Dirdjaja, N.,Krauth-Siegel, R.L.,Engels, B.,Opatz, T.,Schindelin, H.,Hellmich, U.A. Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes. Angew. Chem. Int. Ed. Engl., 58:3640-3644, 2019 Cited by PubMed: 30605929 DOI: 10.1002/anie.201810470 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation