6GXG

Tryparedoxin from Trypanosoma brucei in complex with CFT

6GXG の概要

• エントリーDOI: 10.2210/pdb6gxg/pdb
• 分子名称: Tryparedoxin, 5-(4-fluorophenyl)-2-methyl-3~{H}-thieno[2,3-d]pyrimidin-4-one, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: covalent inhibitor, photoreduction, inhibitor-induced dimerization, monomer-dimer mixture, oxidoreductase
• 由来する生物種: Trypanosoma brucei brucei; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49024.19

構造登録者

Bader, N.,Wagner, A.,Hellmich, U.,Schindelin, H. (登録日: 2018-06-27, 公開日: 2019-01-16, 最終更新日: 2024-01-17)

• 主引用文献: Wagner, A.,Le, T.A.,Brennich, M.,Klein, P.,Bader, N.,Diehl, E.,Paszek, D.,Weickhmann, A.K.,Dirdjaja, N.,Krauth-Siegel, R.L.,Engels, B.,Opatz, T.,Schindelin, H.,Hellmich, U.A.; Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.; Angew. Chem. Int. Ed. Engl., 58:3640-3644, 2019; PubMed: 30605929; DOI: 10.1002/anie.201810470

実験手法

X-RAY DIFFRACTION (1.6 Å)