6GXB

Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13

6GXB の概要

• エントリーDOI: 10.2210/pdb6gxb/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, ~{N}-[4-[4-[(4-sulfamoylphenyl)carbamoylamino]phenoxy]butyl]ethanamide, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase, caii mutant to caix mimic, ca inhibitor, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29330.36

構造登録者

Brynda, J.,Rezacova, P.,Pospisilova, K. (登録日: 2018-06-27, 公開日: 2019-05-08, 最終更新日: 2024-01-17)

• 主引用文献: Pospisilova, K.,Knedlik, T.,Brynda, J.,Rezacova, P.,Sacha, P.,Schimer, J.,Kral, V.,Cigler, P.,Navratil, V.,Subr, V.,Konvalinka, J.; Inhibitor-Polymer Conjugates as a Versatile Tool for Detection and Visualization of Cancer-Associated Carbonic Anhydrase Isoforms; Acs Omega, 4:6746-6756, 2019; DOI: 10.1021/acsomega.9b00596

実験手法

X-RAY DIFFRACTION (1.35 Å)