6GS4

Crystal structure of peptide transporter DtpA-nanobody in complex with valganciclovir

6GS4 の概要

• エントリーDOI: 10.2210/pdb6gs4/pdb
• 分子名称: Dipeptide and tripeptide permease A, nanobody, [(2~{S})-2-[(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)methoxy]-3-oxidanyl-propyl] (2~{S})-2-azanyl-3-methyl-butanoate, ... (5 entities in total)
• 機能のキーワード: peptide transporter, membrane protein, complex with nanobody, slc15 family member
• 由来する生物種: Escherichia coli K-12; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70235.34

構造登録者

Ural-Blimke, Y.,Flayhan, A.,Quistgaard, E.M.,Loew, C. (登録日: 2018-06-13, 公開日: 2019-01-30, 最終更新日: 2024-01-17)

• 主引用文献: Ural-Blimke, Y.,Flayhan, A.,Strauss, J.,Rantos, V.,Bartels, K.,Nielsen, R.,Pardon, E.,Steyaert, J.,Kosinski, J.,Quistgaard, E.M.,Low, C.; Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1.; J. Am. Chem. Soc., 141:2404-2412, 2019; PubMed: 30644743; DOI: 10.1021/jacs.8b11343

実験手法

X-RAY DIFFRACTION (2.645 Å)