The structure of mouse AsterA (GramD1a) with 25-hydroxy cholesterol

Summary for 6GQF

DescriptorGRAM domain-containing protein 1A, 25-HYDROXYCHOLESTEROL, GLYCEROL (3 entities in total)
Functional Keywordscholesterol, plasma membrane, endoplasmic reticulum, lipid transport
Biological sourceMus musculus (Mouse)
Total number of polymer chains4
Total molecular weight105815.7
Fairall, L.,Gurnett, J.E.,Vashi, D.,Sandhu, J.,Tontonoz, P.,Schwabe, J.W.R. (deposition date: 2018-06-07, release date: 2018-09-26, Last modification date: 2018-10-17)
Primary citation
Sandhu, J.,Li, S.,Fairall, L.,Pfisterer, S.G.,Gurnett, J.E.,Xiao, X.,Weston, T.A.,Vashi, D.,Ferrari, A.,Orozco, J.L.,Hartman, C.L.,Strugatsky, D.,Lee, S.D.,He, C.,Hong, C.,Jiang, H.,Bentolila, L.A.,Gatta, A.T.,Levine, T.P.,Ferng, A.,Lee, R.,Ford, D.A.,Young, S.G.,Ikonen, E.,Schwabe, J.W.R.,Tontonoz, P.
Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.
Cell, 175:514-529.e20, 2018
PubMed: 30220461 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2018.08.033
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2562 0.8% 2.1% 3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6gqf
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Molmil generated image of 6gqf
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Molmil generated image of 6gqf
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