6GQ3

Human asparagine synthetase (ASNS) in complex with 6-diazo-5-oxo-L-norleucine (DON) at 1.85 A resolution

Summary for 6GQ3

• Entry DOI: 10.2210/pdb6gq3/pdb
• Descriptor: Asparagine synthetase [glutamine-hydrolyzing], 5-OXO-L-NORLEUCINE, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: l-asparagine biosynthesis, breast cancer, inhibitor development, biosynthetic protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 129997.70

Authors

Zhu, W.,Radadiya, A.,Bisson, C.,Jin, Y.,Nordin, B.E.,Imasaki, T.,Wenzel, S.,Sedelnikova, S.E.,Berry, A.H.,Nomanbhoy, T.K.,Kozarich, J.W.,Takagi, Y.,Rice, D.W.,Richards, N.G.J. (deposition date: 2018-06-07, release date: 2019-09-18, Last modification date: 2024-01-17)

• Primary citation: Zhu, W.,Radadiya, A.,Bisson, C.,Wenzel, S.,Nordin, B.E.,Martinez-Marquez, F.,Imasaki, T.,Sedelnikova, S.E.,Coricello, A.,Baumann, P.,Berry, A.H.,Nomanbhoy, T.K.,Kozarich, J.W.,Jin, Y.,Rice, D.W.,Takagi, Y.,Richards, N.G.J.; High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.; Commun Biol, 2:345-345, 2019; PubMed: 31552298; DOI: 10.1038/s42003-019-0587-z

Experimental method

X-RAY DIFFRACTION (1.85 Å)