6GPH

Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with AMPCP

Summary for 6GPH

Entry DOI	10.2210/pdb6gph/pdb
Related	6GP4 6GP8 6GPF
Descriptor	Heat shock protein HSP 90-alpha, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	chaperone, hsp90, ntd, alpha, k112a, complex, ampcp, nucleotide
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29188.88
Authors	Tassone, G.,Pozzi, C.,Mangani, S.,Botta, M. (deposition date: 2018-06-05, release date: 2018-10-03, Last modification date: 2024-01-17)
Primary citation	Tassone, G.,Mangani, S.,Botta, M.,Pozzi, C. Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart. Biochim Biophys Acta Proteins Proteom, 1866:1190-1198, 2018 Cited by PubMed: 30248409 DOI: 10.1016/j.bbapap.2018.09.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation