6GOT
Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(phenethylthio)benzenesulfonamide
Summary for 6GOT
| Entry DOI | 10.2210/pdb6got/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | lyase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29832.06 |
| Authors | Ferraroni, M.,Supuran, C.T.,Angeli, A. (deposition date: 2018-06-04, release date: 2018-10-03, Last modification date: 2024-01-17) |
| Primary citation | Angeli, A.,Tanini, D.,Capperucci, A.,Malevolti, G.,Turco, F.,Ferraroni, M.,Supuran, C.T. Synthesis of different thio-scaffolds bearing sulfonamide with subnanomolar carbonic anhydrase II and IX inhibitory properties and X-ray investigations for their inhibitory mechanism. Bioorg. Chem., 81:642-648, 2018 Cited by PubMed: 30253337DOI: 10.1016/j.bioorg.2018.09.028 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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