6GLM

Crystal structure of hMTH1 N33A in complex with LW14 in the absence of acetate

Summary for 6GLM

Descriptor7,8-dihydro-8-oxoguanine triphosphatase, 1~{H}-imidazo[4,5-b]pyridin-2-amine, SULFATE ION, ... (4 entities in total)
Functional Keywordsinhibitor, complex, hydrolase, dna repair, fragment
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight21388.17
Authors
Eberle, S.A.,Wiedmer, L.,Sledz, P.,Caflisch, A. (deposition date: 2018-05-23, release date: 2019-02-20)
Primary citation
Eberle, S.A.,Wiedmer, L.,Sledz, P.,Caflisch, A.
hMTH1 N33A in complex with LW14
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22120 1.6%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6glm
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Molmil generated image of 6glm
rotated about x axis by 90°
Molmil generated image of 6glm
rotated about y axis by 90°