6GKY

Crystal structure of Coclaurine N-Methyltransferase (CNMT) bound to N-methylheliamine and SAH

6GKY の概要

• エントリーDOI: 10.2210/pdb6gky/pdb
• 関連するPDBエントリー: 6GKV
• 分子名称: Coclaurine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 6,7-dimethoxy-2,4-dihydro-1~{H}-isoquinolin-3-one (3 entities in total)
• 機能のキーワード: n-methylheliamine, coclaurine n-methyltransferase, transferase
• 由来する生物種: Coptis japonica (Japanese goldthread)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83324.88

構造登録者

Dunstan, M.S.,Levy, C.W. (登録日: 2018-05-22, 公開日: 2018-06-06, 最終更新日: 2024-05-15)

• 主引用文献: Bennett, M.R.,Thompson, M.L.,Shepherd, S.A.,Dunstan, M.S.,Herbert, A.J.,Smith, D.R.M.,Cronin, V.A.,Menon, B.R.K.,Levy, C.,Micklefield, J.; Structure and Biocatalytic Scope of Coclaurine N-Methyltransferase.; Angew. Chem. Int. Ed. Engl., 57:10600-10604, 2018; PubMed: 29791083; DOI: 10.1002/anie.201805060

実験手法

X-RAY DIFFRACTION (2.847 Å)