6GJB

Erk2 signalling protein

6GJB の概要

• エントリーDOI: 10.2210/pdb6gjb/pdb
• 分子名称: Mitogen-activated protein kinase 1, SULFATE ION, [(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[4-[1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-2-oxidanylidene-pyridin-4-yl]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate, ... (4 entities in total)
• 機能のキーワード: erk2, inhibitor, reversible probe, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43689.37

構造登録者

O'Reilly, M. (登録日: 2018-05-16, 公開日: 2019-01-02)

• 主引用文献: Lebraud, H.,Surova, O.,Courtin, A.,O'Reilly, M.,Valenzano, C.R.,Nordlund, P.,Heightman, T.D.; Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe.; Chem Sci, 9:8608-8618, 2018; PubMed: 30568786; DOI: 10.1039/c8sc02754d

実験手法

X-RAY DIFFRACTION (1.82 Å)