6GIU
Human IMPase with L-690330
Summary for 6GIU
| Entry DOI | 10.2210/pdb6giu/pdb |
| Descriptor | Inositol monophosphatase 1, MANGANESE (II) ION, [1-(4-oxidanylphenoxy)-1-phosphono-ethyl]phosphonic acid, ... (5 entities in total) |
| Functional Keywords | impase, complex, lithium, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 63170.16 |
| Authors | Kraft, L.V.,Roe, S.M. (deposition date: 2018-05-15, release date: 2018-10-17, Last modification date: 2024-01-17) |
| Primary citation | Kraft, L.,Roe, S.M.,Gill, R.,Atack, J.R. Co-crystallization of human inositol monophosphatase with the lithium mimetic L-690,330. Acta Crystallogr D Struct Biol, 74:973-978, 2018 Cited by PubMed Abstract: Lithium, which is still the gold standard in the treatment of bipolar disorder, has been proposed to inhibit inositol monophosphatase (IMPase) and is hypothesized to exert its therapeutic effects by attenuating phosphatidylinositol (PI) cell signalling. Drug-discovery efforts have focused on small-molecule lithium mimetics that would specifically inhibit IMPase without exhibiting the undesired side effects of lithium. L-690,330 is a potent bisphosphonate substrate-based inhibitor developed by Merck Sharp & Dohme. To aid future structure-based inhibitor design, determination of the exact binding mechanism of L-690,330 to IMPase was of interest. Here, the high-resolution X-ray structure of human IMPase in complex with L690,330 and manganese ions determined at 1.39 Å resolution is reported. PubMed: 30289407DOI: 10.1107/S2059798318010380 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.39 Å) |
Structure validation
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