6GIH

Crystal Structure of CK2alpha with CAM187 bound

6GIH の概要

• エントリーDOI: 10.2210/pdb6gih/pdb
• 分子名称: Casein kinase II subunit alpha, ACETATE ION, [3-chloranyl-5-(1~{H}-indol-4-yl)phenyl]methanamine, ... (4 entities in total)
• 機能のキーワード: ck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39406.21

構造登録者

Brear, P.,Iegre, J.,North, A.,De Fusco, C.,Georgiou, K.,Lubin, A.,Carro, L.,Sore, H.,Hyvonen, M.,Spring, D. (登録日: 2018-05-11, 公開日: 2018-05-23, 最終更新日: 2024-01-17)

• 主引用文献: Brear, P.,North, A.,Iegre, J.,Hadje Georgiou, K.,Lubin, A.,Carro, L.,Green, W.,Sore, H.F.,Hyvonen, M.,Spring, D.R.; Novel non-ATP competitive small molecules targeting the CK2 alpha / beta interface.; Bioorg. Med. Chem., 26:3016-3020, 2018; PubMed: 29759799; DOI: 10.1016/j.bmc.2018.05.011

実験手法

X-RAY DIFFRACTION (1.96 Å)