6GGH

Human jak1 kinase domain in complex with inhibitor

6GGH の概要

分子名称Tyrosine-protein kinase JAK1, ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide (3 entities in total)
機能のキーワードjanus kinase 1 kinase domain (jak1), transferase
由来する生物種Homo sapiens (Human)
ポリマー鎖数2
分子量合計68361.98
構造登録者
Read, J.A.,Augustin, M.,Lammens, A. (登録日: 2018-05-03, 公開日: 2019-05-22)
主引用文献
Nilsson, M.
Inhibition of local lung inflammation by a potent and selective JAK1 inhibitor; activation of JAK1, but not JAK3, is critical to IL-4R mediated immune cell signalling
To Be Published,
実験手法
X-RAY DIFFRACTION (1.7 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2704 0.2% 0.6% 4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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