6GGH

Human jak1 kinase domain in complex with inhibitor

6GGH の概要

• エントリーDOI: 10.2210/pdb6ggh/pdb
• 分子名称: Tyrosine-protein kinase JAK1, ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide (3 entities in total)
• 機能のキーワード: janus kinase 1 kinase domain (jak1), transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68361.98

構造登録者

Read, J.A.,Augustin, M.,Lammens, A. (登録日: 2018-05-03, 公開日: 2019-05-22, 最終更新日: 2024-01-17)

• 主引用文献: Nilsson, M.; Inhibition of local lung inflammation by a potent and selective JAK1 inhibitor; activation of JAK1, but not JAK3, is critical to IL-4R mediated immune cell signalling; To Be Published,

実験手法

X-RAY DIFFRACTION (1.7 Å)