6GGA
p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9284
Summary for 6GGA
Entry DOI | 10.2210/pdb6gga/pdb |
Descriptor | Cellular tumor antigen p53, (7-bromanyl-9-ethyl-carbazol-3-yl)methyl-methyl-azanium, ZINC ION, ... (4 entities in total) |
Functional Keywords | p53, transcription factor, tumor supressor, cancer therapy, oncogenic mutant, protein misfolding, small-molecule stabilizer, molecular chaperone, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 49828.90 |
Authors | Joerger, A.C.,Bauer, M.R. (deposition date: 2018-05-03, release date: 2019-05-22, Last modification date: 2024-01-17) |
Primary citation | Bauer, M.R.,Jones, R.N.,Tareque, R.K.,Springett, B.,Dingler, F.A.,Verduci, L.,Patel, K.J.,Fersht, A.R.,Joerger, A.C.,Spencer, J. A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. Future Med Chem, 11:2491-2504, 2019 Cited by PubMed: 31633398DOI: 10.4155/fmc-2019-0181 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55000123008 Å) |
Structure validation
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